The Brain Plasticity lab is at the ground floor of a 2024-built state-of-the-art modern laboratory, in a neighborhood rich in cutting-edge research institutions. The “Energy & Memory” team benefits from a large experimental space with optimal layout. Thanks to our integrated approach and to the exceptional working conditions at ESPCI-PSL, our team is a world leader in the study of the interplay between energy metabolism and memory.
Our premises include 6 chambers equipped with our custom-built automated training set-up that will provide unequalled capacity for high-throughput behavioral studies in memory assays. Thanks to our automated olfactory conditioning set-ups, the memory of about 300 genotypes can be tested daily.
To monitor variations of energy fluxes in connection with neuron-glia coupling, we developed a specific expertise in the use of genetically-encoded fluorescent probes for energy metabolites, which we monitor in vivo in the drosophila brain by 2-photon microscopy. We benefit from 3 in vivo imaging stations, including 2 multi-photon microscopes tuned for our own use.
We possess a collection of more than 1,000 Drosophila mutants, many of which were established or tuned by our team. For behavioral experiments, flies are are raised in dedicated chambers with controled temperature, humidity, and activated carbon filtered air.
